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Noakhali Science and Technology University

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Department of Pharmacy

Academic Profile of Dr. Md. Shahid Sarwar

Dr. Md. Shahid Sarwar

About Dr. Md. Shahid Sarwar

Dr. Sarwar obtained his PhD in 2019 as an awardee of the prestigious Hong Kong PhD Fellowship Scheme (HKPFS) from Hong Kong Baptist University. His PhD research focused on screening of potential cytotoxic compounds in multiple cancer cell lines including colorectal, breast, pancreatic, melanoma and lung cancer cells, as well as studies of their structure-activity relationship and mechanism of action in colorectal cancer cells and xenograft mice model. He has a good publication track record with a total impact factor about 80. Moreover, he presented the outcomes of his research in several conferences in the USA, UK, Denmark, Japan, Hong Kong and Bangladesh.

Dr. Sarwar is currently working with several research projects as PI and co-PI.

Principal Investigator (PI): 

1. Study of prevalence and genetic variants of MMP-1, MMP-3, MMP-7 and MMP-13 genes with the risk of breast cancer in Bangladeshi population.

Funding source:  Ministry of Science and Technology under Special Allocation for Science and Technology (2020-21).

2. Association of genetic variants of matrix metalloproteinases with the risk of breast cancer in Bangladeshi population. 

Funding source: Research Cell of NSTU (2020-21).

 

Co-PI:

1. Effect of fish supplementation on nutritional status of adolescent girls: A randomized-controlled trial in Bangladesh.

Funding source: Bangladesh Agricultural Research Council (BARC) (2019-20).

Publications

 

  1. Aziz MA, Sarwar MS (Corresponding author), Akter T, Uddin MS, Xun S, Zhu Y, Islam MS, Hongjie H. Polyphenolic molecules targeting STAT3 pathway for the treatment of cancer. Life Sciences 2021, 268: 118999 (Elsevier). Impact Factor: 3.65. 
  2. Sarwar MS, Xia Y, Liang ZM, Tsang SW, Zhang HJ. Mechanistic pathways and molecular targets of plant-derived anticancer ent-kaurane diterpenes. Biomolecules 2020; 10: 144 (MDPI). Impact Factor: 4.082.
  3. Uddin MS, Mamun AA, Alghamdi BS, Tewari D, Jeandet P, Sarwar MS, Ashraf GM. Epigenetics of Glioblastoma Multiforme: From Molecular Mechanisms to Therapeutic Approaches. Seminars in Cancer Biology 2020 (Elsevier). Impact Factor: 11.09.
  4. Xia Y, Lam CS, Li W, Sarwar MS, Liu K, Lee KM, Zhang HJ, Tsang SW. Flexicaulin A, an ent-kaurane diterpenoid, activates p21 and inhibits the proliferation of colorectal carcinoma cells through a non-apoptotic mechanism. International Journal of Molecular Sciences 2019; 20(8): 1917 (MDPI). Impact Factor: 4.183.
  5. Sarwar MS, Zhang HJ, Tsang SW. Perspectives of Plant Natural Products in Inhibition of Cancer Invasion and Metastasis by Regulating Multiple Signaling Pathways. Current Medicinal Chemistry. 2018; 25(38):5057-5087 (Bentham Science). Impact Factor: 3.693.
  6. Zhao CL, Sarwar MS (Co-First Author), Ye JH, Ku CF, Li WF, Luo GY, Zhang JJ, Xu J, Huang ZF, Tsang SW, Pan LT, Zhang HJ. Isolation, evaluation of bioactivity and structure determination of amethinol A, a prototypic amethane diterpene from Isodon amethystoides bearing a six/five/seven-membered carbon-ring system. Acta Crystallogr C Struct Chem. 2018; 74(Pt 5):635-640 (Wiley Online). Impact Factor: 1.09.
  7. Sarwar MS, Lin Z, Ku CF, Guan Y, Xiao H, Shi X, Wang H, Bian Z, Tsang SW, Zhang HJ. Protective effect of dihydro-resveratrol against lung injury in rats with cerulein-induced acute pancreatitis. Planta Medica 2016; 82(S 01): S1-S381 (Conference abstract). Impact Factor: 2.746. 
  8. Hossain MF, Mamun AA, Shah MA, Hasana S, Bulbul IJ, Sarwar MS, Mansouri RA, Ashraf GM, Rauf A. Exploring the multimodal role of phytochemicals by modulating cellular signal pathways to combat age-related neurodegeneration. Science of the Total Environment 2020; 725: 138313 (Elsevier). Impact Factor: 6.551. 
  9. Uddin MS, Mamun AA, Kabir MT, Ahmad J, Jeandet P, Sarwar MS, Ashraf GM, Aleya L. Neuroprotective role of polyphenols against oxidative stress-mediated neurodegeneration. European Journal of Pharmacology 2020; 173412 (Elsevier). Impact Factor: 3.263.
  10. Mamun A, Uddin MS, Bashar MFB, Zaman S, Begum Y, Bulbul IJ, Islam MS, Mathew B, Ashraf G, Amran M, Sarwar MS, Bin-Jumah MN, Mousa SA, Abdel-Daim MM. Molecular Insights into the Therapeutic Promise of Targeting APOE4 for Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity 2020; Article ID: 5086250 (Hindawi). Impact Factor: 4.868.
  11. Muhammad SB, Hassan F, Bhowmik KK, Millat MS, Sarwar MS, Aziz MA, Barek MA, Uddin MS, Ferdous M, Islam MS. Detection of association of IL1β, IL4R, and IL6 gene polymorphisms with cervical cancer in the Bangladeshi women by tetra-primer ARMS-PCR method. Int Immunopharmacol 2020; 10:107131 (Elsevier). (Impact Factor: 3.943). 
  12. Datta A,  Zahora FT, Aziz MA, Uddin MS, Ferdous M, Millat MS, Sarwar MS, Barek MA, Jafrin S, Nahar S, Islam MS. Association study of IL10 gene polymorphisms (rs1800872 and rs1800896) with cervical cancer in the Bangladeshi women. Int Immunopharmacol 2020 Oct 15;89(Pt B):107091 (Elsevier). Impact Factor: 3.943. 
  13. Dash R, Emran TB, Paul A, Sarwar MS et al. Effects of Five Bangladeshi Plant Extracts on In vitro Thrombolysis and Cytotoxicity. Pharmacognosy Res. 2016; 8(3):176-180. (PubMed). Impact Factor: 1.630.
  14. Bhowmick R, Sarwar MS, Dewan SM et al. In vivo analgesic, antipyretic, and anti-inflammatory potential in Swiss albino mice and in vitro thrombolytic activity of hydroalcoholic extract from Litsea glutinosa leaves. Biological Research, 2014; 47:54 (PubMed). Impact Factor: 2.482.
  15. Sajib AI, Dewan SMR, Das A, Sarwar MS et al. In vitro antimicrobial activity study and in vivo antiemetic, antinociceptive activity evaluation of leaves extract of Erioglossumrubiginosum using experimental animal model. Oriental Pharmacy and Experimental Medicine, 15(2): 135-140 (Springer). Impact Factor: 0.710.
  16. Hossain MD, Sarwar MS, Dewan SM et al. Investigation of total phenolic content and antioxidant activities of Azadirachta indica roots. Avicenna Journal of Phytomedicine, 2014; 4(2): 97-102 (PubMed).
  17. Sarwar MS, Bank S, Sarkar RC et al. Effect of socio-economic status and estimation of lipid peroxidation and antioxidant in preeclamptic pregnant women. Hypertension in Pregnancy, 2015; 34(1):125-135 (PubMed). Impact Factor: 1.80.
  18. Sarwar MS, Ahmed S, Ullah MS et al. Comparative study of serum zinc, copper, manganese and iron in pre-eclamptic pregnant women. Biological Trace Element Research, 2013; 154(1):14-20 (PubMed). Impact Factor: 2.431.
  19. Sarwar MS, Adnan T, Hossain MD et al. Evaluation of serum lipid profile in patients with hypertension living in a coastal region of Bangladesh. Arzneimittel-Forschung/Drug Research, 2014; 64:353-357 (PubMed). Impact Factor: 1.760.
  20. Sarwar MS, Islam MS, Baker SME et al. Resistant hypertension: Underlying causes and treatment. Arzneimittel-Forschung/Drug Research, 2013; 63(5): 217-223 (PubMed). Impact Factor: 1.760.
  21. Das A, Sarwar MS, Hossain MS, Karmakar P et al. Elevated Serum Lipid Peroxidation and Reduced Vitamin C and Trace Element Concentrations Are Correlated With Epilepsy. Clin EEG Neurosci. 2019; 50(1):63-72 (SAGE). Impact Factor: 1.822.
  22. Adnan MT, Amin MN, Uddin MG, Hussain MS, Sarwar MS et al. Increased concentration of serum MDA, decreased antioxidants and altered trace elements and macro-minerals are linked to obesity among Bangladeshi population. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 2019; 13: 933-938 (Elsevier).
  23. Amin MN, Liza KF, Sarwar MS et al. Effect of lipid peroxidation, antioxidants, macro minerals and trace elements on eczema. Archives of Dermatological Research, 307(7):  617-623 (PubMed).  Impact Factor: 2.309.
  24. Uddin MS, Mamun AA, Takeda S, Sarwar MS, Begum MM. Analyzing the chance of developing dementia among geriatric people: a cross-sectional pilot study in Bangladesh. Psychogeriatrics. 2019; 19(2):87-94.
  25. Chowdhury MI, Hasan M, Islam MS, Sarwar MS et al. Elevated serum MDA and depleted non-enzymatic antioxidants, macro-minerals and trace elements are associated with bipolar disorder. Journal of Trace Elements in Medicine and Biology 2017; 39: 162–168. (Elsevier).Impact Factor: 2.895.
  26. Haque MM, Moghala MMR, Sarwar MS et al. Low serum selenium concentration is associated with preeclampsia in pregnant women from Bangladesh. Journal of Trace Elements in Medicine and Biology 2016, 33: 21-25 (Elsevier). Impact Factor: 2.895.
  27. Uddin MS, Mamun AA, Iqbal MA, Sarwar MS et al., Internet Addiction Disorder and Its Pathogenicity to Psychological Distress and Depression among University Students: A Cross-Sectional Pilot Study in Bangladesh. Psychology 2016; 7: 1126-1137.
  28. Uddin MS, Mamun AA, Iqbal MA, Sarwar MS et al. Medicine that Causes Memory Loss: Risk of Neurocognitive Disorders. International Neuropsychiatric Disease Journal 2016; 8(1): 1-18.
  29. Nahar Z, Sarwar MS, Islam MS et al. Determination of serum antioxidant vitamins, glutathione and MDA levels in panic disorder patients. Arzneimittel-Forschung/Drug Research, Germany, 2013; 63:424-428 (PubMed). Impact Factor: 1.760.
  30. Bhowmick R, Sarwar MS, Dewan SMR et al. Comparative evaluation of antidiabetic activity of crude methanolic extract of leaves, fruits, roots and aerial parts of Coccinia grandis. Journal of Plant Sciences 2015; 2(6-1): 19-23.
  31. Bhowmick R, Sarwar MS, Dewan SMR et al. Characterization of chemical groups, and investigation of cytotoxic and antioxidant activity of Litsea glutinosa leaves. Journal of Plant Sciences 2015; 2(6-1): 24-29.
  32. Zannah S, Islam M, Ali Y, Sarwar MS et al. Antidiabetics in combination with hydroxychloroquine improve antioxidant and hepatoprotective activities in alloxan-induced diabetic rats. Bangladesh Pharmaceutical Journal 2015; 18(1): 72-77.
  33. Noor MAA, Islam MZ, Hosain MS, Sarwar MS et al. Analgesic and anti-inflammatory activity of methanol extract of Xanthosoma sagittifolium. Journal of Pharmacognosy and Phytochemistry 2015; 4(3): 181-185.
  34. Basak A, Uddin MMN, Sarwar MS et al.Exploration of analgesic activity of the ethanolic extract of Erythrina variegate bark. Journal of the Analgesics 2015; 2 (2), 37-42.
  35. Akter S, Rahman MA, Azad MAK, Sarwar MS et al. Antidiabetic and thrombolytic effects of ethanolic extract of Spilanthes paniculata leaves. Journal of Plant Sciences 2014; 2(6-1): 13-18.
  36. Rahman MM, Sarwar MS, Das A MS et al. Evaluation of Cytotoxic and Anthelmintic Activity of Plant Roots of Clerodendrum viscosum (Family: Verbenaceae). Journal of Pharmacognosy and Phytochemistry 2013; 2(4): 119-122.
  37. Hasanuzzaman M, Sayeed MSB, Islam MS, Sarwar MS et al. Preliminary antimicrobial activity and cytotoxicity of plant extracts (roots) of Coccinia grandis (Family: Cucurbitaceae).  International Journal of Pharmaceutical Science and Research, 2013; 4(4): 1466-1468.
  38. Hossain MS, Rahaman MZ, Banik S, Sarwar MS et al. Prevalence of the metabolic syndrome in diabetic patients living in a coastal region of Bangladesh. International Journal of Pharmaceutical Science and Research, 2012; 3(8): 2633-2638.

CONFERENCE PRESENTATIONS

  1. Sarwar MS, Xia Y, Fai KC, Tsang SW, Wong MS, Zhang HJ. Exploring the mechanism of action of a novel ent-kaurene diterpenoid for the treatment of colon cancer. NCRI Cancer Conference (4-6 November 2018), Glasgow, UK.
  2. Sarwar MS, Tsang SW, Wong MS, Zhang HJ. Anticancer activity and mechanism of action of a novel ent-kaurane diterpenoid. 2017 Meeting of the American Society of Pharmacognosy(27 July 2017 to 1 August 2017), Portland, Oregon, USA.
  3. Sarwar MS, Lin Z, Ku CF, Guan Y, Xiao H, Shi X, Wang H, Bian Z, Tsang SW, Zhang HJ. Protective effect of dihydro-resveratrol against lung injury in rats with cerulein-induced acute pancreatitis.  9th Joint Natural Products Conference (24-27 August, 2016), Copenhagen, Denmark.
  4. Sarwar MS,Tsang SW, Wong MS, Zhang HJ. Cytotoxic activity, structure activity relationship and mechanism of action of ent-kaurane diterpenoids. 13th International Postgraduate Symposium in Chinese Medicine (17 August 2017), Hong Kong.
  5. Sarwar MS, Adnan T, Islam MS. Evaluation of serum antioxidant, trace element and macronutrient status in obese individuals. 6th International Summer Program (25-29 August 2014), Tokyo Medical & Dental University, Tokyo, Japan.
  6. Sarwar MS, Dewan SMR, Chowdhury MI, Hasan M, Islam MS. Islam MS. Status of serum macro minerals and trace elements in bipolar disorder. International Conference on Biological Sciences: Food, Health and Environmental Perspectives (8 August 2015), University of Rajshahi, Bangladesh.
  7. Islam MT, Sarwar MS, Rashid M. Fenofibrate potentiates the antihyperglycemic, antidyslipidemic and hepatoprotective activity of pioglitazone on alloxan-induced diabetic rats. International Conference on Biological Sciences: Food, Health and Environmental Perspectives (8 August 2015), University of Rajshahi, Bangladesh.
  8. Sarwar MS, Islam MS, Rashid M. Evaluation of serum antioxidant, trace element and macro minerals status in myocardial infarction. 6th International Seminar on Safe Food- Healthy Nation (21 March 2015), Bangladesh Agricultural University (BAU), Mymensingh, Bangladesh.
  9. Sarwar MS, Hossain MD, Hossain MS, Islam MS. Alteration of serum trace elements and the complexicity of interelement relations in patients with preeclampsia. 19th Conference of the Islamic World Academy of Sciences (IAS) (5-9 May, 2013), Dhaka, Bangladesh.
  10. Sarwar MS, Hossain MD, Sarkar RC, Islam MS. Preeclampsia: A threat for safe motherhood and perinatal outcomes in rural area of Bangladesh. 1st International Symposium on Pharmaceutical Sciences: A Global Approach (26 February 2013), Chittagong, Bangladesh.

Experiences and Activities

TEACHING EXPERIENCES

Associate Professor, Department of Pharmacy, Noakhali Science & Technology University, Bangladesh 

Assistant Professor, Department of Pharmacy, Noakhali Science & Technology University, Bangladesh 

Lecturer, Department of Pharmacy, Noakhali Science & Technology University, Bangladesh 

Lecturer, Department of Pharmacy, Southeast University, Banani, Dhaka-1213, Bangladesh 

 

ADMINISTRATIVE WORKS

Assistant Provost, Abdul Malek Ukil Students Residence Hall, NSTU, Bangladesh (October 2019 to October 2021).

 

FELLOWSHIPS, GRANTS AND AWARDS

1. Hong Kong PhD Fellowship Scheme (HKPFS)

2016-19

2. Travel Grant to attend NCRI Cancer Conference in UK

2018

3. Travel Grant to attend American Society of Pharmacognosy (ASP) Annual Meeting in Portland, Oregon, USA

2017

4. Travel Grant to attend 9th Joint Natural Products Conference in Copenhagen, Denmark

2016

5. 6th International Summer Program (ISP)-2014 Fellowship by Tokyo Medical and Dental University, Japan

2014

MEMBERSHIPS

  1. Lead Guest Editor, Journal of Plant Science

            http://membership.sciencepublishinggroup.com/sarwar

  1. Reviewer, Arzneimittel-Forschung/Drug Research.
  2. Reviewer, Pharmaceutical Biology.
  3. Reviewer, Journal of Research in Pharmacy Practice.
  4. Former Convener, Committee for Project and Research, Department of Pharmacy, Southeast University, Dhaka, Bangladesh
  5.  Former Member, Laboratory development committee, Department of Pharmacy, Southeast University, Dhaka, Bangladesh.